Interesting question. I doubt it would be worth it for a basic attack. The real question is, would it work with a spell? In that case you could (in theory) use profundity, blood rite, and a Tier2/AM to put some mega hate on your tank.... if it works with a spell.
FFXIV: Taiga Halak, Fabul
FFXI: Talina, Valefor (retired)